League of Legends' console and mobile version, Wild Rift, will have some fundamental changes since it was built from the ground up to conform to the users of inputs that are not mouse and keyboard. It will also differ in champion rosters though.
Riot Games' 10th-anniversary announcement extravaganza included Wild Rift, the version of League of Legends for consoles and mobile devices. This version will feature different mechanics in order to make the game more controller and touchscreen-friendly but that is just the tip of the iceberg of all the differences the two games will have.
One of the most important differences will be the different champion pools. This much was confirmed by Riot themselves via an interview with Barry Carry on YouTube.
Namely, Wild Rift will not have all the champions from League of Legends. While this may sound disappointing to some fans, the answer given by the Rioter was also followed by a question that "should be asked" - will all the Wild Rift champions be present in League of Legends?
While this is not the explicit "there are champions exclusive to Wild Rift" statement, it is the closest thing we will get right up until they get revealed. Furthermore, this direction would make sense for Riot Games in order to keep both Wild Rift and traditional League of Legends appealing as opposed to one overshadowing the other.
Besides, even the existing champions will behave differently in the two games. The best example is the curved Enchanted Crystal Arrow that will be controllable much like Yuumi's skill shot.
On top of that, a more explicit confirmation was the one regarding esports. Wild Rift will have esports of its own but it remains to be seen how and whether the events would interact with those of League of Legends for the purposes of cross-promotion. The most recent All-Star event was filled to the brim with Teamfight Tactics content, after all.