Hardsuit Labs and Paradox Interactive recently teased the first faction in Vampire the Masquerade: Bloodlines 2. There are five in total and they are organisations separate from the clans we are already used to in World of Darkness.
Vampire: The Masquerade: Bloodlines 2 will apparently have a different kind of groups on top of the clans we saw in the original bloodlines. There are five factions in Seattle and they can consist of vampires from different clans unified by the same goal.
Therefore, the factions shouldn't be confused with clans. Just like any other type of organisation, a faction can be tightly or loosely knit. In the case of factions in Bloodlines 2, each seems to be unified by the goal of attempting to control the city.
Each of the five factions has a unique history, characteristics and motivations. Players will apparently be able to choose which faction to join, betray or even manipulate them into fighting each other.
The Pioneers are the first factions were are introduced to. They are led by Lou Grand, the longest-reigning prince of Seattle but that doesn't mean their power is absolute. It's waning, in fact and reestablishing said power will likely be what they will aim to use the protagonist for.
They are somewhat similar to Anarchs since Pioneers are aiming to preserve the frontier-like nature of Seattle since it's the last city without a centuries-old power structure.
While they share the passionate and independent spirit with the Anarchs, they don't look keenly at each other due to Pioneers leaning more towards the pragmatic solutions rather than hot-headed outbursts.
According to the official description, The Pioneers are longing for returning to the days of yore, to Seattle as it once was. Considering they are old enough to remember these days, Pioneers are more loyal to each other than other factions, a byproduct of centuries in the same environment.
Despite controlling Seattle for the longest while in history, their power has diminished over the last two decades. That is by no means the end of Pioneers though as their long reign left them with enough money they could potentially use to produce influence when necessary.